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KMID : 0857020050200010038
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Kosin Medical Journal
2005 Volume.20 No. 1 p.38 ~ p.45
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The Realtionship between Gamma-Glutamyltransferase and Metabolic Syndrome in the Non Alcoholic Health Screen Examinees
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Park Ji-Eun
Choi Young-Sik
Kim Nang-Hee
Nam Ji-Hyeon
Kim Ju-Hun
Park Jung-Pil
Park Yo-Han
Kim Jin-Ha
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Abstract
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Background: Gamma-glutamyltransferase (γGTP) is one of the biliary enzymes, and is synthesized in epithelial cells of the intrahepatic bile duct. Increased γGTP is conventionally interpreted as a marker of alcohol abuse and/or liver damage. Recently, an association between γGTP and metabolic syndrome such as diagetes, obesity, hyperlipidemia, and hypertension has been reported. The aim of this study was to assess the association between γGTP activity and parameters of meatabolic syndrome in the non-alcoholic health screen examinees.
Mothods: A total of 4,100 health screen examinees (2,051 men, 2,059 women) who participated in health screening at the health promotion center in Kosin Medical Center from March, 1997 to December. 2003 were enrolled in this study. All participants have no evidence of viral hepatitis and alcohol abuse. The clinical, biochemical and metabolic parameters analyzed by multiple regression and logistic methods.
Results: Almost of all variables (age, weight, blood pressure, body mass index (BMI), waist circumference (WC), total cholesterol, triglyceride, fasting blood glucose and γGTP) except high density lipoprotein (HDL) cholesterol were significantly high in men than women (p＜0.05). When subjects were grouped according to the γGTP level, group Ⅰ (0∼≤20 U/L) and group Ⅱ (20 U/L＜∼≤40 U/L) and group Ⅲ (＞40 U/L), significant differences were noticed in almost of all variables (weight, blood pressure, BMI, WC, total cholesterol, triglyceride, fasting blood glucose) among each group (p＜0.01). The age adjusted odds ratio between WC and abnormal γGTP level was 1.760 in men and 2.475 in women (p＜0.01). As subjects were grouped according to their number of components in metabolic syndrome, the numbers of subjects with abnormal γGTP concentration were increased according to the numbers of components in metabolic syndrome (p＜0.05). There was significant positive correlation among waist circumference (r=0.192, p＜0.01), waist and hit ratio (r=0.293, p＜0.01), systolic blood pressure (r=0.115, p＜0.01). total cholesterol (r=0.135, p＜0.01), triglyceride(r=0.228, p＜0.01) and γGTP.
Conclusion: These results suggested that increased γGTP level in non alcoholic health examinees is closely associated with metabolic syndrome. Elavated γGTP may not always indicate increased alcohol consumption, but may simply suggest the existence of the metabolic syndrome.
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KEYWORD
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Metabolic syndrome, gamma-glutamyltranferase, metabolic parameters
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